Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ2
Variant:p.C149F
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KCNJ2

NM_000891.3:p.C149F

Associated Papers

Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels.

Lee SJ et al.

Nature Communications, 2013

A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.

Chang HK et al.

Biophysical Journal, 2005

Conformational changes in Kir2.1 channels during NH4+-induced inactivation.

Chang HK et al.

The Journal of Biological Chemistry, 2003

Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.

Fujiwara Y et al.

The Journal of General Physiology, 2002

Architecture of a K+ channel inner pore revealed by stoichiometric covalent modification.

Lu T et al.

Neuron, 1999

Probing pore topology and conformational changes of Kir2.1 potassium channels by cysteine scanning mutagenesis.

Kubo Y et al.

Febs Letters, 1998

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."