Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ2
Variant:p.D172A
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KCNJ2

NM_000891.3:p.D172A

Associated Papers

Subunit gating resulting from individual protonation events in Kir2 channels.

Maksaev G et al.

Nature Communications, 2023

37507406 (PubMed )
Supplement: 41467_2023_40058_MOESM2_ESM.pdf

Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.

Amorós I et al.

Biochemical Pharmacology, 2013

Physical determinants of strong voltage sensitivity of K(+) channel block.

Xu Y et al.

Nature Structural & Molecular Biology, 2009

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome.

El Harchi A et al.

Journal of Molecular and Cellular Cardiology, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."