Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ2
Variant:p.V194L
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KCNJ2

NM_000891.3:p.V194L

Associated Papers

Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).

Rosenhouse-Dantsker A et al.

The Journal of Biological Chemistry, 2012

Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore.

Rosenhouse-Dantsker A et al.

Biophysical Journal, 2011

Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.

Rosenhouse-Dantsker A et al.

Channels (austin, Tex.), 0

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