Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ2
Variant:p.D255A
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KCNJ2

NM_000891.3:p.D255A

Associated Papers

Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.

Xynogalos P et al.

Naunyn-schmiedeberg's Archives of Pharmacology, 2014

The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.

Kurata HT et al.

The Journal of General Physiology, 2007

Evidence for sequential ion-binding loci along the inner pore of the IRK1 inward-rectifier K+ channel.

Shin HG et al.

The Journal of General Physiology, 2005

Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.

Pegan S et al.

Nature Neuroscience, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."