Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ2
Variant:p.D259A
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KCNJ2

NM_000891.3:p.D259A

Associated Papers

Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference.

Koepple C et al.

The Journal of Pharmacology and Experimental Therapeutics, 2017

The molecular basis of chloroethylclonidine block of inward rectifier (Kir2.1 and Kir4.1) K(+) channels.

Rodríguez-Menchaca AA et al.

Pharmacological Reports : Pr, 2016

Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.

Xynogalos P et al.

Naunyn-schmiedeberg's Archives of Pharmacology, 2014

Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.

Amorós I et al.

Biochemical Pharmacology, 2013

Inwardly rectifying potassium channels: their structure, function, and physiological roles.

Hibino H et al.

Physiological Reviews, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."