Associated Papers
Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference.
Koepple C et al.
The Journal of Pharmacology and Experimental Therapeutics, 2017
Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.
Xynogalos P et al.
Naunyn-schmiedeberg's Archives of Pharmacology, 2014
The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel.
Huang CW et al.
Pflugers Archiv : European Journal of Physiology, 2014
Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.
Amorós I et al.
Biochemical Pharmacology, 2013
Physical determinants of strong voltage sensitivity of K(+) channel block.
Xu Y et al.
Nature Structural & Molecular Biology, 2009
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