Associated Papers
Ethosuximide: Subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels.
Shalomov B et al.
British Journal of Pharmacology, 2025
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.
Strauss A et al.
Nature Communications, 2024
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
Mancinelli C et al.
Biorxiv : the Preprint Server for Biology, 2024
Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP.
Luebbers A et al.
Structure (london, England : 1993), 2024
Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels.
Nguyen H et al.
Frontiers in Physiology, 2024
Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers.
Lee J et al.
Science Advances, 2023
Mechanism of PKCε regulation of cardiac GIRK channel gating.
Gada KD et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023
From Crosstalk to Synergism: The Combined Effect of Cholesterol and PI(4,5)P2 on Inwardly Rectifying Potassium Channels.
Bukiya AN et al.
Advances in Experimental Medicine and Biology, 2023
A novel small-molecule selective activator of homomeric GIRK4 channels.
Cui M et al.
The Journal of Biological Chemistry, 2022
Consequences of somatic mutations of GIRK1 detected in primary malign tumors on expression and function of G-protein activated, inwardly rectifying, K+ channels.
Pelzmann B et al.
Frontiers in Oncology, 2022
Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels.
Reddy HP et al.
Iscience, 2021
Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6.
Rai D et al.
Journal of Neurochemistry, 2021
Mechanisms of differential desensitization of metabotropic glutamate receptors.
Abreu N et al.
Cell Reports, 2021
Identification of a G-Protein-Independent Activator of GIRK Channels.
Zhao Y et al.
Cell Reports, 2020
Conformational pathway provides unique sensitivity to a synaptic mGluR.
Habrian CH et al.
Nature Communications, 2019
Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.
Chen IS et al.
British Journal of Pharmacology, 2019
Synergistic activation of G protein-gated inwardly rectifying potassium channels by cholesterol and PI(4,5)P2.
Bukiya AN et al.
Biochimica Et Biophysica Acta. Biomembranes, 2017
Cholesterol increases the open probability of cardiac KACh currents.
Bukiya AN et al.
Biochimica Et Biophysica Acta, 2015
A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels.
Mahajan R et al.
Science Signaling, 2013
Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase.
Treiber F et al.
Biochimica Et Biophysica Acta, 2013
Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.
Yow TT et al.
British Journal of Pharmacology, 2011
Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers.
Leal-Pinto E et al.
The Journal of Biological Chemistry, 2010
Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit.
Rusinova R et al.
Pflugers Archiv : European Journal of Physiology, 2009
Multiple residues in the p-region and m2 of murine kir 2.1 regulate blockage by external ba.
Lee YM et al.
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2009
Phosphoinositide-mediated gating of inwardly rectifying K(+) channels.
Logothetis DE et al.
Pflugers Archiv : European Journal of Physiology, 2007
Mechanosensitivity of GIRK channels is mediated by protein kinase C-dependent channel-phosphatidylinositol 4,5-bisphosphate interaction.
Zhang L et al.
The Journal of Biological Chemistry, 2004
The selectivity filter may act as the agonist-activated gate in the G protein-activated Kir3.1/Kir3.4 K+ channel.
Claydon TW et al.
The Journal of Biological Chemistry, 2003
Na+ promotes the dissociation between Galpha GDP and Gbeta gamma, activating G protein-gated K+ channels.
Rishal I et al.
The Journal of Biological Chemistry, 2003
Molecular determinants for activation of G-protein-coupled inward rectifier K+ (GIRK) channels by extracellular acidosis.
Mao J et al.
The Journal of Biological Chemistry, 2002
The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment.
Jin T et al.
Molecular Cell, 2002
Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins.
He C et al.
The Journal of Biological Chemistry, 2002
Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site.
Rogalski SL et al.
The Journal of Biological Chemistry, 2001
Functional properties of a truncated recombinant GIRK5 potassium channel.
Salvador C et al.
Biochimica Et Biophysica Acta, 2001
Coupling Gbetagamma-dependent activation to channel opening via pore elements in inwardly rectifying potassium channels.
Sadja R et al.
Neuron, 2001
Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.
Slesinger PA
Biophysical Journal, 2001
TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.
Rogalski SL et al.
The Journal of Biological Chemistry, 2000
Identification of a potassium channel site that interacts with G protein betagamma subunits to mediate agonist-induced signaling.
He C et al.
The Journal of Biological Chemistry, 1999
GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels.
Kennedy ME et al.
The Journal of Biological Chemistry, 1999
Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.
Vivaudou M et al.
The Journal of Biological Chemistry, 1997
Control of channel activity through a unique amino acid residue of a G protein-gated inwardly rectifying K+ channel subunit.
Chan KW et al.
Proceedings of the National Academy of Sciences of the United States of America, 1996
A unique P-region residue is required for slow voltage-dependent gating of a G protein-activated inward rectifier K+ channel expressed in Xenopus oocytes.
Kofuji P et al.
The Journal of Physiology, 1996
A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels.
Cui M et al.
The Journal of Biological Chemistry, 0