Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ3
Variant:p.S170P
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KCNJ3

NM_002239.4:p.S170P

Associated Papers

Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels.

Chen IS et al.

British Journal of Pharmacology, 2019

The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel.

Meng XY et al.

Scientific Reports, 2016

The selectivity filter may act as the agonist-activated gate in the G protein-activated Kir3.1/Kir3.4 K+ channel.

Claydon TW et al.

The Journal of Biological Chemistry, 2003

The pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels.

Alagem N et al.

Biophysical Journal, 2003

The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment.

Jin T et al.

Molecular Cell, 2002

Coupling Gbetagamma-dependent activation to channel opening via pore elements in inwardly rectifying potassium channels.

Sadja R et al.

Neuron, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."