Varaico: Literature-Extracted Genetic Variants

Gene:KCNJ3
Variant:p.N217D
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KCNJ3

NM_002239.4:p.N217D

Associated Papers

The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers.

Touhara KK et al.

Elife, 2016

The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels.

Zhang Z et al.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2010

Inwardly rectifying potassium channels: their structure, function, and physiological roles.

Hibino H et al.

Physiological Reviews, 2010

A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2).

Rosenhouse-Dantsker A et al.

Nature Chemical Biology, 2008

Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site.

Rogalski SL et al.

The Journal of Biological Chemistry, 2001

Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels.

Ho IH et al.

The Journal of Physiology, 1999

Molecular determinants for sodium-dependent activation of G protein-gated K+ channels.

Ho IH et al.

The Journal of Biological Chemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."