Associated Papers
Mutagenesis-Centered Integrative Approaches for Identifying Binding Sites in Ion Channels and Uncovering Modulatory Mechanisms.
Rosenhouse-Dantsker A
Advances in Experimental Medicine and Biology, 2026
Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP2 binding.
Xynogalos P et al.
Naunyn-schmiedeberg's Archives of Pharmacology, 2023
Cardiac potassium inward rectifier Kir2: Review of structure, regulation, pharmacology, and arrhythmogenesis.
Reilly L et al.
Heart Rhythm, 2021
Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference.
Koepple C et al.
The Journal of Pharmacology and Experimental Therapeutics, 2017
Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2.
Rosenhouse-Dantsker A et al.
Computational and Structural Biotechnology Journal, 2014
Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore.
Rosenhouse-Dantsker A et al.
Biophysical Journal, 2011
Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol.
Epshtein Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2009
Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.
Rosenhouse-Dantsker A et al.
Channels (austin, Tex.), 0
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