Associated Papers
The W101C KCNJ5 Mutation Induces Slower Pacing by Constitutively Active GIRK Channels in hiPSC-Derived Cardiomyocytes.
Kayser A et al.
International Journal of Molecular Sciences, 2023
Mechanism of PKCε regulation of cardiac GIRK channel gating.
Gada KD et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023
A novel small-molecule selective activator of homomeric GIRK4 channels.
Cui M et al.
The Journal of Biological Chemistry, 2022
A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5).
Shalomov B et al.
The Journal of Physiology, 2022
On the mechanism of GIRK2 channel gating by phosphatidylinositol bisphosphate, sodium, and the Gβγ dimer.
Li D et al.
The Journal of Biological Chemistry, 2019
Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2).
Ha J et al.
The Journal of Biological Chemistry, 2018
Population-Specific Associations of Deleterious Rare Variants in Coding Region of P2RY1-P2RY12 Purinergic Receptor Genes in Large-Vessel Ischemic Stroke Patients.
Janicki PK et al.
International Journal of Molecular Sciences, 2017
Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus.
Bukiya AN et al.
The Journal of Biological Chemistry, 2017
A Critical Gating Switch at a Modulatory Site in Neuronal Kir3 Channels.
Adney SK et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2015
Cholesterol increases the open probability of cardiac KACh currents.
Bukiya AN et al.
Biochimica Et Biophysica Acta, 2015
Aromatic-aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process.
Garneau L et al.
The Journal of General Physiology, 2014
A computational model predicts that Gβγ acts at a cleft between channel subunits to activate GIRK1 channels.
Mahajan R et al.
Science Signaling, 2013
Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase.
Treiber F et al.
Biochimica Et Biophysica Acta, 2013
Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ.
Deng W et al.
The Journal of Biological Chemistry, 2012
Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers.
Leal-Pinto E et al.
The Journal of Biological Chemistry, 2010
A discrete alcohol pocket involved in GIRK channel activation.
Aryal P et al.
Nature Neuroscience, 2009
Characterizations of a loss-of-function mutation in the Kir3.4 channel subunit.
Calloe K et al.
Biochemical and Biophysical Research Communications, 2007
Phosphoinositide-mediated gating of inwardly rectifying K(+) channels.
Logothetis DE et al.
Pflugers Archiv : European Journal of Physiology, 2007
Characterization of the heteromeric potassium channel formed by kv2.1 and the retinal subunit kv8.2 in Xenopus oocytes.
Czirják G et al.
Journal of Neurophysiology, 2007
New roles for a key glycine and its neighboring residue in potassium channel gating.
Rosenhouse-Dantsker A et al.
Biophysical Journal, 2006
Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation.
Mirshahi T et al.
Biophysical Journal, 2006
Inhibition of a background potassium channel by Gq protein alpha-subunits.
Chen X et al.
Proceedings of the National Academy of Sciences of the United States of America, 2006
Long chain CoA esters as competitive antagonists of phosphatidylinositol 4,5-bisphosphate activation in Kir channels.
Rapedius M et al.
The Journal of Biological Chemistry, 2005
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor.
Murata Y et al.
Nature, 2005
betaL-betaM loop in the C-terminal domain of G protein-activated inwardly rectifying K(+) channels is important for G(betagamma) subunit activation.
Finley M et al.
The Journal of Physiology, 2004
Molecular determinants for activation of G-protein-coupled inward rectifier K+ (GIRK) channels by extracellular acidosis.
Mao J et al.
The Journal of Biological Chemistry, 2002
Distinct sites on G protein beta gamma subunits regulate different effector functions.
Mirshahi T et al.
The Journal of Biological Chemistry, 2002
N-terminal tyrosine residues within the potassium channel Kir3 modulate GTPase activity of Galphai.
Ippolito DL et al.
The Journal of Biological Chemistry, 2002
The (beta)gamma subunits of G proteins gate a K(+) channel by pivoted bending of a transmembrane segment.
Jin T et al.
Molecular Cell, 2002
Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins.
He C et al.
The Journal of Biological Chemistry, 2002
Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site.
Rogalski SL et al.
The Journal of Biological Chemistry, 2001
Functional properties of a truncated recombinant GIRK5 potassium channel.
Salvador C et al.
Biochimica Et Biophysica Acta, 2001
Visualization of a functional Galpha q-green fluorescent protein fusion in living cells. Association with the plasma membrane is disrupted by mutational activation and by elimination of palmitoylation sites, but not be activation mediated by receptors or AlF4-.
Hughes TE et al.
The Journal of Biological Chemistry, 2001
TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.
Rogalski SL et al.
The Journal of Biological Chemistry, 2000
Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.
Zhang H et al.
Nature Cell Biology, 1999
Identification of a potassium channel site that interacts with G protein betagamma subunits to mediate agonist-induced signaling.
He C et al.
The Journal of Biological Chemistry, 1999
Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.
Vivaudou M et al.
The Journal of Biological Chemistry, 1997
Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix.
Rosenhouse-Dantsker A et al.
Channels (austin, Tex.), 0
Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop.
Rosenhouse-Dantsker A et al.
Channels (austin, Tex.), 0
Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.
Rosenhouse-Dantsker A et al.
Channels (austin, Tex.), 0
A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels.
Cui M et al.
The Journal of Biological Chemistry, 0