Associated Papers
Mutagenesis-Centered Integrative Approaches for Identifying Binding Sites in Ion Channels and Uncovering Modulatory Mechanisms.
Rosenhouse-Dantsker A
Advances in Experimental Medicine and Biology, 2026
From Crosstalk to Synergism: The Combined Effect of Cholesterol and PI(4,5)P2 on Inwardly Rectifying Potassium Channels.
Bukiya AN et al.
Advances in Experimental Medicine and Biology, 2023
Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning.
Coyote-Maestas W et al.
Elife, 2022
35639599 (PubMed )
Supplement: elife-76903-data1.zip › SourceData › input_data › KCNJ_Clinvar_0325322_edited_annotations_.xlsx › clinvar_KCNJx_0325322
Synergistic activation of G protein-gated inwardly rectifying potassium channels by cholesterol and PI(4,5)P2.
Bukiya AN et al.
Biochimica Et Biophysica Acta. Biomembranes, 2017
Cholesterol increases the open probability of cardiac KACh currents.
Bukiya AN et al.
Biochimica Et Biophysica Acta, 2015
Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ.
Deng W et al.
The Journal of Biological Chemistry, 2012
A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2).
Rosenhouse-Dantsker A et al.
Nature Chemical Biology, 2008
Eicosanoids inhibit the G-protein-gated inwardly rectifying potassium channel (Kir3) at the Na+/PIP2 gating site.
Rogalski SL et al.
The Journal of Biological Chemistry, 2001
Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions.
Zhang H et al.
Nature Cell Biology, 1999
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