Varaico: Literature-Extracted Genetic Variants

Gene:KCNK1
Variant:p.K274E
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KCNK1

NM_002245.4:p.K274E

Associated Papers

Emerging Roles of TWIK-1 Heterodimerization in the Brain.

Cho CH et al.

International Journal of Molecular Sciences, 2017

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.

Christensen AH et al.

Journal of Molecular and Cellular Cardiology, 2016

A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes.

Hwang EM et al.

Nature Communications, 2014

Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification.

Ma L et al.

The Journal of Biological Chemistry, 2012

TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia.

Ma L et al.

Science Signaling, 2011

One SUMO is sufficient to silence the dimeric potassium channel K2P1.

Plant LD et al.

Proceedings of the National Academy of Sciences of the United States of America, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."