Associated Papers
Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.
Willegems K et al.
Nature Communications, 2022
Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements.
Chen L et al.
Frontiers in Physiology, 2022
ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state.
Eldstrom J et al.
The Journal of General Physiology, 2021
Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome.
Seebohm G et al.
The Journal of Biological Chemistry, 2001
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