Associated Papers
Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements.
Chen L et al.
Frontiers in Physiology, 2022
Molecular determinants of Kv7.1/KCNE1 channel inhibition by amitriptyline.
Villatoro-Gómez K et al.
Biochemical Pharmacology, 2018
Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter.
Lerche C et al.
Molecular Pharmacology, 2007
Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels.
Seebohm G et al.
The Journal of Physiology, 2005
Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels.
Seebohm G et al.
Circulation Research, 2003
Molecular determinants of KCNQ1 channel block by a benzodiazepine.
Seebohm G et al.
Molecular Pharmacology, 2003
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