Associated Papers
State-dependent regulation of the Kv7.2 channel voltage sensor by QO-58.
Kanyo R et al.
British Journal of Pharmacology, 2026
Electrophysiological Abnormalities and Pharmacological Corrections of Pathogenic Missense Variants in KCNQ3.
Wu X et al.
Neuroscience Bulletin, 2025
Lipophilic compounds restore function to neurodevelopmental-associated KCNQ3 mutations.
Edmond MA et al.
Communications Biology, 2024
Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener.
Manville RW et al.
Communications Biology, 2023
Intracellular zinc protects Kv7 K+ channels from Ca2+/calmodulin-mediated inhibition.
Yang X et al.
The Journal of Biological Chemistry, 2023
General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates.
Liu S et al.
Journal of Medicinal Chemistry, 2022
Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine.
Yang ND et al.
Science Advances, 2022
Triclosan is a KCNQ3 potassium channel activator.
De la Rosa V et al.
Pflugers Archiv : European Journal of Physiology, 2022
Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations.
Martin-Batista E et al.
Frontiers in Molecular Neuroscience, 2021
Familial neonatal seizures caused by the Kv7.3 selectivity filter mutation T313I.
Maghera J et al.
Epilepsia Open, 2020
Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy.
Li J et al.
Molecular Pharmacology, 2020
A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation.
Liu Y et al.
Communications Biology, 2020
The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator.
Redford KE et al.
Communications Biology, 2020
Potassium channels act as chemosensors for solute transporters.
Manville RW et al.
Communications Biology, 2020
M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate.
Manville RW et al.
The Journal of Pharmacology and Experimental Therapeutics, 2020
Cilantro leaf harbors a potent potassium channel-activating anticonvulsant.
Manville RW et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2019
Epilepsy-associated mutations in the voltage sensor of KCNQ3 affect voltage dependence of channel opening.
Barro-Soria R
The Journal of General Physiology, 2019
Investigating an epileptogenic mutation.
Sedwick C
The Journal of General Physiology, 2019
In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner.
Manville RW et al.
Communications Biology, 2019
Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates KCNQ3 K+ channels by interacting with four cytoplasmic channel domains.
Choveau FS et al.
The Journal of Biological Chemistry, 2018
One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels.
Yau MC et al.
The Journal of General Physiology, 2018
Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels.
Manville RW et al.
Molecular Pharmacology, 2018
Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.
Manville RW et al.
Nature Communications, 2018
Direct neurotransmitter activation of voltage-gated potassium channels.
Manville RW et al.
Nature Communications, 2018
A possible link between KCNQ2- and STXBP1-related encephalopathies: STXBP1 reduces the inhibitory impact of syntaxin-1A on M current.
Devaux J et al.
Epilepsia, 2017
PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels.
Kim RY et al.
Proceedings of the National Academy of Sciences of the United States of America, 2017
Sequence determinants of subtype-specific actions of KCNQ channel openers.
Wang AW et al.
The Journal of Physiology, 2017
Endoplasmic reticulum retention of KCNQ2 potassium channel mutants following temperature elevation.
Yu F et al.
Bio-medical Materials and Engineering, 2017
Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate.
Soldovieri MV et al.
Scientific Reports, 2016
The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels.
Kim KS et al.
Biophysical Journal, 2016
Atomic basis for therapeutic activation of neuronal potassium channels.
Kim RY et al.
Nature Communications, 2015
Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.
Kalappa BI et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2015
Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.
Miceli F et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2015
The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K+ Current Amplitudes by Controlling Channel Trafficking.
Choveau FS et al.
Plos One, 2015
The neuronal serum- and glucocorticoid-regulated kinase 1.1 reduces neuronal excitability and protects against seizures through upregulation of the M-current.
Miranda P et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2013
Distinct subunit contributions to the activation of M-type potassium channels by PI(4,5)P2.
Telezhkin V et al.
The Journal of General Physiology, 2012
Pore determinants of KCNQ3 K+ current expression.
Choveau FS et al.
Biophysical Journal, 2012
Pore helix-S6 interactions are critical in governing current amplitudes of KCNQ3 K+ channels.
Choveau FS et al.
Biophysical Journal, 2012
Regions of KCNQ K(+) channels controlling functional expression.
Choveau FS et al.
Frontiers in Physiology, 2012
Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.
Mistry HD et al.
Hypertension (dallas, Tex. : 1979), 2011
Kv7 channels can function without constitutive calmodulin tethering.
Gómez-Posada JC et al.
Plos One, 2011
The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels.
Soh H et al.
Molecular Pharmacology, 2010
A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression.
Gómez-Posada JC et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2010
Ca2+/calmodulin disrupts AKAP79/150 interactions with KCNQ (M-Type) K+ channels.
Bal M et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2010
Selective interaction of syntaxin 1A with KCNQ2: possible implications for specific modulation of presynaptic activity.
Regev N et al.
Plos One, 2009
Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.
Lange W et al.
Molecular Pharmacology, 2009