Associated Papers
Lipophilic compounds restore function to neurodevelopmental-associated KCNQ3 mutations.
Edmond MA et al.
Communications Biology, 2024
Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener.
Manville RW et al.
Communications Biology, 2023
Triclosan is a KCNQ3 potassium channel activator.
De la Rosa V et al.
Pflugers Archiv : European Journal of Physiology, 2022
The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator.
Redford KE et al.
Communications Biology, 2020
Potassium channels act as chemosensors for solute transporters.
Manville RW et al.
Communications Biology, 2020
M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate.
Manville RW et al.
The Journal of Pharmacology and Experimental Therapeutics, 2020
Cilantro leaf harbors a potent potassium channel-activating anticonvulsant.
Manville RW et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2019
In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner.
Manville RW et al.
Communications Biology, 2019
Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels.
Manville RW et al.
Molecular Pharmacology, 2018
Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.
Manville RW et al.
Nature Communications, 2018
Direct neurotransmitter activation of voltage-gated potassium channels.
Manville RW et al.
Nature Communications, 2018
The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine.
Syeda R et al.
The Journal of Biological Chemistry, 2016
Atomic basis for therapeutic activation of neuronal potassium channels.
Kim RY et al.
Nature Communications, 2015
Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.
Kalappa BI et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2015
The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels.
Soh H et al.
Molecular Pharmacology, 2010
Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.
Lange W et al.
Molecular Pharmacology, 2009