Varaico: Literature-Extracted Genetic Variants

Gene:KDR
Variant:p.Y951F
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KDR

NM_002253.4:p.Y951F

Associated Papers

Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation.

Manni S et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2014

Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.

Jinnin M et al.

Nature Medicine, 2008

VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.

Matsumoto T et al.

The Embo Journal, 2005

Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively.

Zeng H et al.

The Journal of Biological Chemistry, 2001

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.

Warner AJ et al.

The Biochemical Journal, 2000

VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor.

Wu LW et al.

The Journal of Biological Chemistry, 2000

Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.

Dougher M et al.

Oncogene, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."