Varaico: Literature-Extracted Genetic Variants

Gene:KEAP1
Variant:p.E444*
Back to variants list

KEAP1

NM_203500.2:p.E444*

Associated Papers

PPIA dictates NRF2 stability to promote lung cancer progression.

Lu W et al.

Nature Communications, 2024

Targeting NFE2L2/KEAP1 Mutations in Advanced NSCLC With the TORC1/2 Inhibitor TAK-228.

Paik PK et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2023

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer.

Bartolacci C et al.

Nature Communications, 2022

35882862 (PubMed )
Supplement: 41467_2022_31963_MOESM13_ESM.xlsx › Sheet1

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation.

Gong M et al.

Cell Communication and Signaling : Ccs, 2020

Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites.

Saigusa D et al.

Cancer Science, 2020

31828882 (PubMed )
Supplement: CAS-111-667-s002.xlsx › Table_S2

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

MacLeod AK et al.

British Journal of Cancer, 2016

27824809 (PubMed )
Supplement: bjc2016363x1.docx
Select a paper to view details
UCSC Genome Browser·Imprint·Privacy·Terms·Feedback·Email Updates·

Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."