Varaico: Literature-Extracted Genetic Variants

Gene:KEAP1
Variant:p.G332C
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KEAP1

NM_203500.2:p.G332C

Associated Papers

Integrated histopathologic modeling of detailed tumor subtypes and actionable biomarkers.

Boehm KM et al.

Biorxiv : the Preprint Server for Biology, 2025

Landscape of cancer associated EpCAM mutations: molecular modeling, predictive insights and impact on patient survival.

Dhotare PS et al.

Bmc Cancer, 2025

40597801 (PubMed )
Supplement: 12885_2025_14455_MOESM1_ESM.zip › Supplementary_tables.pdf

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer.

Pillai R et al.

Science Advances, 2024

38536921 (PubMed )
Supplement: sciadv.adm9859_sm.pdf

Clinical perspectives on the value of testing for STK11 and KEAP1 mutations in advanced NSCLC.

Shiller M et al.

Frontiers in Oncology, 2024

39703851 (PubMed )
Supplement: DataSheet2.xlsx › Supplemental_data

Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer.

Pillai R et al.

Biorxiv : the Preprint Server for Biology, 2023

Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors.

Cobain EF et al.

Jama Oncology, 2021

33630025 (PubMed )
Supplement: jamaoncol-e207987-s004.xlsx › Table

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.

Wohlhieter CA et al.

Cell Reports, 2020

33264619 (PubMed )
Supplement: NIHMS1651256-supplement-6.pdf

KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition.

Binkley MS et al.

Cancer Discovery, 2020

Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.

Koyama T et al.

Bmc Cancer, 2019

30709382 (PubMed )
Supplement: 12885_2019_5313_MOESM2_ESM.xlsx › supplementary_2_filtered

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden.

Chalmers ZR et al.

Genome Medicine, 2017

28420421 (PubMed )
Supplement: 13073_2017_424_MOESM7_ESM.xlsx › Sheet1

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Taguchi K et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."