Varaico: Literature-Extracted Genetic Variants

Gene:KEAP1
Variant:p.P318L
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KEAP1

NM_203500.2:p.P318L

Associated Papers

KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation.

Shao N et al.

Advanced Science (weinheim, Baden-wurttemberg, Germany), 2020

33173725 (PubMed )
Supplement: ADVS-7-2001018-s001.pdf

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone.

Torrente L et al.

Redox Biology, 2020

32007910 (PubMed )
Supplement: mmc2.xlsx › Table_1_LuSCC

Cross-cancer profiling of molecular alterations within the human autophagy interaction network.

Lebovitz CB et al.

Autophagy, 2015

26208877 (PubMed )
Supplement: kaup-11-09-1067362-s001.zip › 1067362_supplemental_files › 2014AUTO0485R1-s03.xlsx › LUSC-mutations

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Hast BE et al.

Cancer Research, 2014

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.

Hast BE et al.

Cancer Research, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."