Varaico: Literature-Extracted Genetic Variants

Gene:KEAP1
Variant:p.R272L
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KEAP1

NM_203500.2:p.R272L

Associated Papers

Clinical utility of liquid biopsy next-generation sequencing for advanced non-small cell lung cancer in the Netherlands.

de Bitter TJJ et al.

Scientific Reports, 2025

40830613 (PubMed )
Supplement: 41598_2025_13667_MOESM2_ESM.xlsx › Supplementary_Table_2

KEAP1 mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancer.

Bambach NE et al.

Frontiers in Oncology, 2025

41573641 (PubMed )
Supplement: Table2.xlsx › Sheet1

PPIA dictates NRF2 stability to promote lung cancer progression.

Lu W et al.

Nature Communications, 2024

An Investigation of the Immune Microenvironment and Genome during Lung Adenocarcinoma Development.

Wang Q et al.

Journal of Cancer, 2024

38370388 (PubMed )
Supplement: jcav15p1687s1.zip › Supplementary_Materials › Clinical_and_Genomic_Data.xlsx › Gene_mutation

Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.

Sakthikumar S et al.

Veterinary and Comparative Oncology, 2023

37248814 (PubMed )
Supplement: supplement_1.xlsx › Supp._Table_5

The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations.

Kulkarni A et al.

Oncotarget, 2021

33889302 (PubMed )
Supplement: oncotarget-12-791-s001.pdf

NFE2L2/KEAP1 Mutations Correlate with Higher Tumor Mutational Burden Value/PD-L1 Expression and Potentiate Improved Clinical Outcome with Immunotherapy.

Xu X et al.

The Oncologist, 2020

Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites.

Saigusa D et al.

Cancer Science, 2020

31828882 (PubMed )
Supplement: CAS-111-667-s002.xlsx › Table_S2
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."