Varaico: Literature-Extracted Genetic Variants

Gene:KEAP1
Variant:p.Q193H
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KEAP1

NM_203500.2:p.Q193H

Associated Papers

A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth.

Roy N et al.

Cancer Discovery, 2025

PPIA dictates NRF2 stability to promote lung cancer progression.

Lu W et al.

Nature Communications, 2024

The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations.

Kulkarni A et al.

Oncotarget, 2021

33889302 (PubMed )
Supplement: oncotarget-12-791-s001.pdf

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.

MacLeod AK et al.

British Journal of Cancer, 2016

NCI-60 whole exome sequencing and pharmacological CellMiner analyses.

Reinhold WC et al.

Plos One, 2014

25032700 (PubMed )
Supplement: pone.0101670.s001.xlsx › Supplementary_Table_1
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."