Varaico: Literature-Extracted Genetic Variants

Gene:KEAP1
Variant:p.V167F
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KEAP1

NM_203500.2:p.V167F

Associated Papers

Molecular underpinnings of dedifferentiation and aggressiveness in chromophobe renal cell carcinoma.

Kapur P et al.

Jci Insight, 2024

38775158 (PubMed )
Supplement: jciinsight-9-176743-s288.xlsx › Table_S5

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone.

Torrente L et al.

Redox Biology, 2020

32007910 (PubMed )
Supplement: mmc2.xlsx › Table_1_LuSCC

Cross-cancer profiling of molecular alterations within the human autophagy interaction network.

Lebovitz CB et al.

Autophagy, 2015

26208877 (PubMed )
Supplement: kaup-11-09-1067362-s001.zip › 1067362_supplemental_files › 2014AUTO0485R1-s03.xlsx › LUSC-mutations

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.

Hast BE et al.

Cancer Research, 2014

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.

Hast BE et al.

Cancer Research, 2013

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer.

Muscarella LA et al.

Epigenetics, 2011

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Taguchi K et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2011

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."