Associated Papers
A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth.
Roy N et al.
Cancer Discovery, 2025
Bidirectional regulation of KEAP1 BTB domain-based sensor activity.
Suzuki T et al.
Redox Biology, 2025
Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway.
Ting KKY et al.
Scientific Reports, 2024
Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.
Ibrahim L et al.
Cell Chemical Biology, 2023
S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling.
Ko Y et al.
Proceedings of the National Academy of Sciences of the United States of America, 2023
Succinylation of a KEAP1 sensor lysine promotes NRF2 activation.
Ibrahim L et al.
Biorxiv : the Preprint Server for Biology, 2023
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2.
Rosarda JD et al.
Acs Chemical Biology, 2021
Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis.
Fang Y et al.
Redox Biology, 2020
NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
Liu P et al.
Plos Biology, 2020
Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation.
Liu P et al.
Cell Chemical Biology, 2019
Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer.
Kang YP et al.
Elife, 2019
Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation.
Liu S et al.
Biomed Research International, 2019
Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
McMahon M et al.
Toxicology and Applied Pharmacology, 2018
Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.
Cleasby A et al.
Plos One, 2014
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
Adam J et al.
Cancer Cell, 2011
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
Taguchi K et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2011
Cysteine-based regulation of the CUL3 adaptor protein Keap1.
Sekhar KR et al.
Toxicology and Applied Pharmacology, 2010
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.
Hayes JD et al.
Trends in Biochemical Sciences, 2009
Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production.
Cvetko F et al.
The Journal of Biological Chemistry, 0