Varaico: Literature-Extracted Genetic Variants

Gene:KEAP1
Variant:p.A143P
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KEAP1

NM_203500.2:p.A143P

Associated Papers

A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants.

Aboulkassim T et al.

Cell Reports, 2023

The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations.

Kulkarni A et al.

Oncotarget, 2021

33889302 (PubMed )
Supplement: oncotarget-12-791-s001.pdf

Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites.

Saigusa D et al.

Cancer Science, 2020

31828882 (PubMed )
Supplement: CAS-111-667-s002.xlsx › Table_S2
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."