Varaico: Literature-Extracted Genetic Variants

Gene:KEAP1
Variant:p.C23Y
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KEAP1

NM_203500.2:p.C23Y

Associated Papers

Regulation of Cell Proliferation and Nrf2-Mediated Antioxidant Defense: Conservation of Keap1 Cysteines and Nrf2 Binding Site in the Context of the Evolution of KLHL Family.

Shilovsky GA et al.

Life (basel, Switzerland), 2023

Kelch-like proteins: Physiological functions and relationships with diseases.

Shi X et al.

Pharmacological Research, 2019

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Gorrini C et al.

The Journal of Experimental Medicine, 2013

Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers.

Jiao X et al.

Genes, Chromosomes & Cancer, 2012

Somatic mutations of the KEAP1 gene in common solid cancers.

Yoo NJ et al.

Histopathology, 2012

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.

Taguchi K et al.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms, 2011

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.

Lee DF et al.

Molecular Cell, 2009

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.

Hayes JD et al.

Trends in Biochemical Sciences, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."