Varaico: Literature-Extracted Genetic Variants

Gene:KIT
Variant:p.F600Y
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KIT

NM_000222.3:p.F600Y

Associated Papers

Broad spectrum of regorafenib activity on mutant KIT and absence of clonal selection in gastrointestinal stromal tumor (GIST): correlative analysis from the GRID trial.

Jeffers M et al.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2022

35050442 (PubMed )
Supplement: 10120_2021_1274_MOESM1_ESM.docx

Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

Chevrier S et al.

International Journal of Molecular Medicine, 2022

35244186 (PubMed )
Supplement: Supplementary_Data2.xlsx › Feuil1

An update on molecular alterations in melanocytic tumors with emphasis on Spitzoid lesions.

Dimonitsas E et al.

Annals of Translational Medicine, 2018

Mutational profiling of acral melanomas in Korean populations.

Shim JH et al.

Experimental Dermatology, 2017

Towards Personalized Medicine in Melanoma: Implementation of a Clinical Next-Generation Sequencing Panel.

de Unamuno Bustos B et al.

Scientific Reports, 2017

28356599 (PubMed )
Supplement: 41598_2017_606_MOESM2_ESM.xls › Table_S1

COSMIC: High-Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer.

Forbes SA et al.

Current Protocols in Human Genetics, 2016

Frequent KIT mutations in human gastrointestinal stromal tumors.

Xu Z et al.

Scientific Reports, 2014

25080996 (PubMed )
Supplement: srep05907-s1.pdf

The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia.

Bastian BC

Annual Review of Pathology, 2014

Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.

Griewank KG et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013

The somatic affairs of BRAF: tailored therapies for advanced malignant melanoma and orphan non-V600E (V600R-M) mutations.

Ponti G et al.

Journal of Clinical Pathology, 2013

KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.

Tie J et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21239505 (PubMed )
Supplement: 10780432ccr101720-sup-supplementary_tables_s1-s4.pdf

Esophageal melanomas harbor frequent NRAS mutations unlike melanomas of other mucosal sites.

Sekine S et al.

Virchows Archiv : an International Journal of Pathology, 2009

Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemia.

Christiansen DH et al.

Leukemia, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."