Associated Papers
Protective mutations associated with APOE in Alzheimer's disease.
Ma Y et al.
Molecular Psychiatry, 2026
The mediating influence of serum Klotho levels and the KL-VS heterozygosity on telomere shortening in schizophrenia.
Majumdar V et al.
Schizophrenia Research, 2025
The Spectrum of Genetic Risk in Alzheimer Disease.
Karagas N et al.
Neurology. Genetics, 2025
Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration.
Sacchi L et al.
Frontiers in Aging Neuroscience, 2025
Association of KLOTHO gene variants with metabolic and renal function parameters in Mexican patients living with type 2 diabetes.
Mendoza-Carrera F et al.
Journal of Diabetes and Metabolic Disorders, 2024
Role of deleterious nsSNPs of klotho protein and their drug response: a computational mechanical insights.
Jayaraj JM et al.
Journal of Biomolecular Structure & Dynamics, 2024
Genetic and therapeutic landscapes in cohort of pancreatic adenocarcinomas: next-generation sequencing and machine learning for full tumor exome analysis.
Shatalov PA et al.
Oncotarget, 2024
Association Between Klotho Gene Polymorphisms and Urolithiasis: A Meta-Analysis.
Qin J et al.
Journal of the College of Physicians and Surgeons--pakistan : Jcpsp, 2024
Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.
Chen XR et al.
Genes, 2023
Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease.
Cai Y et al.
Alzheimer's Research & Therapy, 2023
No Evidence That Genetic Variation at the Klotho Locus Is Associated With Longevity in Caucasians from the Newcastle 85+ Study and the UK Biobank.
Amin HA et al.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2022
Klotho Polymorphism in Association With Serum Testosterone and Knee Strength in Women After Testosterone Administration.
Ekström L et al.
Frontiers in Physiology, 2022
Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk.
Ali M et al.
Plos One, 2022
Genetic Variants Associated With Resilience in Human and Animal Studies.
Cahill S et al.
Frontiers in Psychiatry, 2022
An Integrated Analysis of Clinical, Genomic, and Imaging Features Reveals Predictors of Neurocognitive Outcomes in a Longitudinal Cohort of Pediatric Cancer Survivors, Enriched with CNS Tumors (Rad ART Pro).
Kline C et al.
Frontiers in Oncology, 2022
Loss of αklotho causes reduced motor ability and short lifespan in zebrafish.
Ogura Y et al.
Scientific Reports, 2021
Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55-87 years.
Müller BW et al.
Scientific Reports, 2021
Genetic signature of human longevity in PKC and NF-κB signaling.
Ryu S et al.
Aging Cell, 2021
KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
Neitzel J et al.
Nature Communications, 2021
Protective genes and pathways in Alzheimer's disease: moving towards precision interventions.
Seto M et al.
Molecular Neurodegeneration, 2021
Rare Variants in Autophagy and Non-Autophagy Genes in Late-Onset Pompe Disease: Suggestions of Their Disease-Modifying Role in Two Italian Families.
Napolitano F et al.
International Journal of Molecular Sciences, 2021
Testing for Interactions Between APOE and Klotho Genotypes on Cognitive, Dementia, and Brain Imaging Metrics in UK Biobank.
Tank R et al.
Journal of Alzheimer's Disease : Jad, 2021
FGFR4 and Klotho Polymorphisms Are Not Associated with Cardiovascular Outcomes in Chronic Kidney Disease.
Sellier AB et al.
American Journal of Nephrology, 2021
Reduced Plasma Levels of α-Klotho and Their Correlation With Klotho Polymorphisms in Elderly Patients With Major Depressive Disorders.
Gao X et al.
Frontiers in Psychiatry, 2021
Association of a single nucleotide polymorphism combination pattern of the Klotho gene with non-cardiovascular death in patients with chronic kidney disease.
Cambray S et al.
Clinical Kidney Journal, 2020
The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study.
Wu PH et al.
Scientific Reports, 2020
KLOTHO polymorphisms and age-related outcomes in community-dwelling older subjects: The São Paulo Ageing & Health (SPAH) Study.
Pereira RMR et al.
Scientific Reports, 2020
Klotho and vitamin D in multiple sclerosis: an Italian study.
Scazzone C et al.
Archives of Medical Science : Ams, 2020
Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis.
Smyth LJ et al.
Bmj Open, 2019
Circulating CD34+ and CD34+VEGFR2+ progenitor cells are associated with KLOTHO KL-VS polymorphism.
Skrzypkowska M et al.
Microvascular Research, 2018
The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes.
Słomiński B et al.
Biochimica Et Biophysica Acta. Molecular Basis of Disease, 2018
Correlation between KLOTHO gene and mild cognitive impairment in the Uygur and Han populations of Xinjiang.
Abulizi P et al.
Oncotarget, 2017
Klotho, APOEε4, cognitive ability, brain size, atrophy, and survival: a study in the Aberdeen Birth Cohort of 1936.
de Vries CF et al.
Neurobiology of Aging, 2017
Longevity Klotho gene polymorphism and the risk of dementia in older men.
Almeida OP et al.
Maturitas, 2017
Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging.
Yokoyama JS et al.
Brain Imaging and Behavior, 2017
Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group.
Mengel-From J et al.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2016
The impact of klotho gene polymorphisms on urinary tract stone disease.
Gürel A et al.
World Journal of Urology, 2016
Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease.
Donate-Correa J et al.
Journal of Cellular and Molecular Medicine, 2016
Protective alleles and modifier variants in human health and disease.
Harper AR et al.
Nature Reviews. Genetics, 2015
Significant roles of anti-aging protein klotho and fibroblast growth factor23 in cardiovascular disease.
Ding HY et al.
Journal of Geriatric Cardiology : Jgc, 2015
Molecular basis of Klotho: from gene to function in aging.
Xu Y et al.
Endocrine Reviews, 2015
Variation in longevity gene KLOTHO is associated with greater cortical volumes.
Yokoyama JS et al.
Annals of Clinical and Translational Neurology, 2015
Renal function and klotho gene polymorphisms among Uygur and Kazak populations in Xinjiang, China.
Xu X et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 2015
N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.
Esapa CT et al.
Plos One, 2015
Is Klotho F352V Polymorphism the Missing Piece of the Bone Loss Puzzle in Renal Transplant Recipients?
Ozdem S et al.
Pharmacology, 2015
Association of Klotho and interleukin 6 gene polymorphisms with aging in Han Chinese population.
Zhang WG et al.
The Journal of Nutrition, Health & Aging, 2014
The association between KL polymorphism and prostate cancer risk in Korean patients.
Kim HJ et al.
Molecular Biology Reports, 2014
Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk.
Tucker Zhou TB et al.
The Journal of Biological Chemistry, 2013
IGF-1 and BRCA1 signalling pathways in familial cancer.
Werner H et al.
The Lancet. Oncology, 2012