Varaico: Literature-Extracted Genetic Variants

Gene:KLF4
Variant:p.K409Q
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KLF4

NM_004235.6:p.K409Q

Associated Papers

The prognostic impact of CDKN2A/B hemizygous deletions in meningioma.

Ippen FM et al.

Neuro-oncology, 2026

Effects of Krüppel-like factor 4 mutation on the clinicopathological characteristics and its related protein expressions in intraductal papillary mucinous neoplasm of the pancreas.

Nagamine Y et al.

Pancreatology : Official Journal of the International Association of Pancreatology (iap) ... [et Al.], 2025

Integrated proteomic and targeted Next Generation Sequencing reveal relevant heterogeneity in lower-grade meningioma and ANXA3 as a new target in NF2 mutated meningiomas.

Shah M et al.

Ebiomedicine, 2025

European Association of Neuro-Oncology guideline on molecular testing of meningiomas for targeted therapy selection.

Sahm F et al.

Neuro-oncology, 2025

Novel germline and somatic variants in familial and sporadic meningioma genes.

Bencheikh BOA et al.

Npj Genomic Medicine, 2025

40374631 (PubMed )
Supplement: 41525_2025_494_MOESM2_ESM.xlsx › Sheet1

The somatic mutation landscape of normal gastric epithelium.

Coorens THH et al.

Nature, 2025

40108450 (PubMed )
Supplement: 41586_2025_8708_MOESM1_ESM.xlsx › Supplementary_Table_6_-_Drivers

cIMPACT-NOW update 8: Clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.

Sahm F et al.

Neuro-oncology, 2025

Recurrent TRAF7-mutated meningioma: Molecular evolution and therapeutic insights.

Pack E et al.

Sage Open Medical Case Reports, 2025

Molecular and histopathological landscape of 131 meningiomas: a retrospective institutional study with insights from cIMPACT-NOW.

Ali RH et al.

Frontiers in Oncology, 2025

GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway.

Ikeuchi H et al.

Oncogene, 2024

39095584 (PubMed )
Supplement: 41388_2024_3105_MOESM2_ESM.xlsx › Supplementary_Table_S6

Genetic characterization and mutational profiling of foramen magnum meningiomas: a multi-institutional study.

Hua L et al.

Journal of Neurosurgery, 2024

A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1.

Graillon T et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2024

38630553 (PubMed )
Supplement: ccr-23-3308_supplementary_table_s1_suppts1.xlsx › Feuil1

Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.

Thirimanne HN et al.

Cell Genomics, 2024

Clinical relevance of somatic mutations in Chinese lung adenocarcinoma and their prognostic implications for survival.

Li T et al.

Cancer Medicine, 2024

38770632 (PubMed )
Supplement: CAM4-13-e7227-s001.xlsx › Table_S2

Meningioma: current updates on genetics, classification, and mouse modeling.

Szulzewsky F et al.

Upsala Journal of Medical Sciences, 2024

Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas.

Tabor JK et al.

Journal of Neurosurgery, 2023

Normal meninges harbor oncogenic somatic mutations in meningioma-driver genes.

Boetto J et al.

Acta Neuropathologica, 2023

Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas.

Youngblood MW et al.

Nature Communications, 2023

37805627 (PubMed )
Supplement: 41467_2023_41926_MOESM3_ESM.xlsx › SD1

Radiomics-Based Prediction of TERT Promotor Mutations in Intracranial High-Grade Meningiomas.

Akkurt BH et al.

Cancers, 2023

Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease.

Mishra-Gorur K et al.

Proceedings of the National Academy of Sciences of the United States of America, 2023

KLF4 transcription factor in tumorigenesis.

He Z et al.

Cell Death Discovery, 2023

Specific gene expression signatures of low grade meningiomas.

Tsitsikov EN et al.

Frontiers in Oncology, 2023

Genomic Landscape of Meningiomas.

Wang JZ et al.

Advances in Experimental Medicine and Biology, 2023

Mutated KLF4(K409Q) in meningioma binds STRs and activates FGF3 gene expression.

Tsytsykova AV et al.

Iscience, 2022

NF2 Alteration/22q Loss Is Associated with Recurrence in WHO Grade 1 Sphenoid Wing Meningiomas.

Sakai Y et al.

Cancers, 2022

35804955 (PubMed )
Supplement: cancers-14-03183-s001.zip › supplementary_table_S4.xlsx › supplementary_table

A new amplicon-based gene panel for next generation sequencing characterization of meningiomas.

Mawrin C et al.

Brain Pathology (zurich, Switzerland), 2022

Prognostic impact of genetic alterations and methylation classes in meningioma.

Berghoff AS et al.

Brain Pathology (zurich, Switzerland), 2022

35213082 (PubMed )
Supplement: BPA-32-e12970-s001.xlsx › Sheet1

The integrated multiomic diagnosis of sporadic meningiomas: a review of its clinical implications.

Robert SM et al.

Journal of Neuro-oncology, 2022

Clinicopathologic Characteristics of Grade 2/3 Meningiomas: A Perspective on the Role of Next-Generation Sequencing.

Kim J et al.

Frontiers in Oncology, 2022

Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas.

Kirches E et al.

Acta Neuropathologica, 2021

Discovering the Molecular Landscape of Meningioma: The Struggle to Find New Therapeutic Targets.

Maggio I et al.

Diagnostics (basel, Switzerland), 2021

Clinical Characteristics and Magnetic Resonance Imaging-Based Prediction of the KLF4K409Q Mutation in Meningioma.

von Spreckelsen N et al.

World Neurosurgery, 2021

Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas.

Jin L et al.

Journal of Neuro-oncology, 2021

Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.

Najm P et al.

Cancer Research, 2021

Meningioma: A Pathology Perspective.

Toland A et al.

Neurosurgery, 2021

Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions.

Fujikura K et al.

Gut, 2021

Associations of pathological diagnosis and genetic abnormalities in meningiomas with the embryological origins of the meninges.

Okano A et al.

Scientific Reports, 2021

Activation of the RAS pathway through uncommon BRAF mutations in mucinous pancreatic cysts without KRAS mutation.

Ren R et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2021

The spatial phenotype of genotypically distinct meningiomas demonstrate potential implications of the embryology of the meninges.

Fountain DM et al.

Oncogene, 2021

Sporadic multiple meningiomas harbor distinct driver mutations.

Juratli TA et al.

Acta Neuropathologica Communications, 2021

Whole-Exome Sequencing Reveals Recurrent but Heterogeneous Mutational Profiles in Sporadic WHO Grade 1 Meningiomas.

González-Tablas M et al.

Frontiers in Oncology, 2021

Expression of transgenes enriched in rare codons is enhanced by the MAPK pathway.

Peterson J et al.

Scientific Reports, 2020

33335127 (PubMed )
Supplement: 41598_2020_78453_MOESM1_ESM.pdf

KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment.

von Spreckelsen N et al.

Acta Neuropathologica Communications, 2020

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."