Varaico: Literature-Extracted Genetic Variants

Gene:KLHL1
Variant:p.M174T
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KLHL1

NM_020866.3:p.M174T

Associated Papers

The impact of single nucleotide polymorphisms on the absorption, distribution, metabolism, and excretion of dietary (poly)phenols: a critical systematic review.

Tosi N et al.

Food & Function, 2025

Endogenous Metabolites-Mediated Communication Between OAT1/OAT3 and OATP1B1 May Explain the Association Between SLCO1B1 SNPs and Methotrexate Toxicity.

Martinez D et al.

Clinical Pharmacology and Therapeutics, 2018

Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of Statins.

Arrigoni E et al.

International Journal of Molecular Sciences, 2017

Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects.

Woo HI et al.

Drug Design, Development and Therapy, 2017

Absence of ethnic differences in the pharmacokinetics of moxifloxacin, simvastatin, and meloxicam among three East Asian populations and Caucasians.

Hasunuma T et al.

British Journal of Clinical Pharmacology, 2016

Genetic and/or non-genetic causes for inter-individual and inter-cellular variability in transporter protein expression: implications for understanding drug efficacy and toxicity.

Koo SH et al.

Expert Opinion on Drug Metabolism & Toxicology, 2015

Pharmacogenetic considerations for acute lymphoblastic leukemia therapies.

Dulucq S et al.

Expert Opinion on Drug Metabolism & Toxicology, 2014

Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sex.

Prasad B et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2014

Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects.

Fahrmayr C et al.

Drug Metabolism Reviews, 2010

UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients.

Onoue M et al.

International Journal of Clinical Oncology, 2009

OATP1B1 polymorphism is a major determinant of serum bilirubin level but not associated with rifampicin-mediated bilirubin elevation.

Zhang W et al.

Clinical and Experimental Pharmacology & Physiology, 2007

Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations.

Jada SR et al.

European Journal of Clinical Pharmacology, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."