Associated Papers
A scalable approach to resolving variants of uncertain significance.
Tejura M et al.
Biorxiv : the Preprint Server for Biology, 2026
Familial Hyperkalemic Hypertension.
Cornelius RJ et al.
Comprehensive Physiology, 2024
Aldosterone defects in infants and young children with hyperkalemia: A single center retrospective study.
Liu X et al.
Frontiers in Pediatrics, 2023
Kelch-like protein 3 in human disease and therapy.
Lin Y et al.
Molecular Biology Reports, 2022
A case report of pseudohypoaldosteronism type II with a homozygous KLHL3 variant accompanied by hyperthyroidism.
Zhang R et al.
Bmc Endocrine Disorders, 2021
Hypertension Accompanied by Hyperaldosteronism, Hyperkalemia, and Hyperchloremic Acidosis: A Case Report and Literature Review.
Yang Y et al.
Case Reports in Endocrinology, 2020
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Fragoza R et al.
Nature Communications, 2019
Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.
Sohara E et al.
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 2016
Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).
Glover M et al.
Clinical Science (london, England : 1979), 2014
Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.
Mori Y et al.
Biochemical and Biophysical Research Communications, 2013
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
Wu G et al.
Febs Letters, 2013
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.
Ohta A et al.
The Biochemical Journal, 2013
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
Errington WJ et al.
Structure (london, England : 1993), 2012
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
Boyden LM et al.
Nature, 2012
[KLHL3 and CULLIN-3: new genes involved in familial hypertension].
Louis-Dit-Picard H et al.
Medecine Sciences : M/s, 0