Varaico: Literature-Extracted Genetic Variants

Gene:KLK6
Variant:p.E166A
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KLK6

NM_002774.4:p.E166A

Associated Papers

Structural insights into the nirmatrelvir-resistant SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design.

Fischer C et al.

Rsc Medicinal Chemistry, 2025

SARS-CoV-2 Resistance to Small Molecule Inhibitors.

Lopez UM et al.

Current Clinical Microbiology Reports, 2024

Distal Protein-Protein Interactions Contribute to SARS-CoV-2 Main Protease Substrate Binding and Nirmatrelvir Resistance.

Lewandowski EM et al.

Biorxiv : the Preprint Server for Biology, 2024

Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease.

Flynn JM et al.

Acs Infectious Diseases, 2023

Detailed Insights into the Inhibitory Mechanism of New Ebselen Derivatives against Main Protease (Mpro) of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).

Sahoo P et al.

Acs Pharmacology & Translational Science, 2023

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."