Varaico: Literature-Extracted Genetic Variants

Gene:KRAS
Variant:p.A146P
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KRAS

NM_004985.5:p.A146P

Associated Papers

Association of TIGIT and CD155 with KRAS, NRAS, BRAF, PIK3CA, and AKT Gene Mutations, MSI Status, and Cytokine Profiles in Colorectal Cancer.

Ochman B et al.

International Journal of Molecular Sciences, 2026

Phosphorylation Protects Oncogenic RAS from LZTR1-Mediated Degradation.

Zhang L et al.

Biorxiv : the Preprint Server for Biology, 2026

Isolated KRAS and NRAS mutations in adults with monocytosis and/or cytopenia(s).

Wang SA et al.

Haematologica, 2025

KRAS-targeted therapies in colorectal cancer: a systematic analysis of mutations, inhibitors, and clinical trials.

Navarro-Jiménez M et al.

Npj Precision Oncology, 2025

Integrative analysis of genomic and transcriptomic data informs precancer progression in the pancreas.

Noller K et al.

Biorxiv : the Preprint Server for Biology, 2025

Clinical features, mutational landscape and their prognostic impact in Chinese paediatric patients with T-cell lymphoblastic lymphoma.

Li Y et al.

British Journal of Haematology, 2025

40958529 (PubMed )
Supplement: supplement_1.zip › Table_S3.xlsx › Sheet1

Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia.

Newman H et al.

Hemasphere, 2025

41306327 (PubMed )
Supplement: HEM3-9-e70269-s013.xlsx › Supplemental_Table_5_-_SSVs

Molecular Profiling of KRAS, NRAS, and BRAF in Colorectal Cancer: Insights From a Libyan Cohort.

Tawel HM et al.

Cureus, 2025

Functional Analysis of Rare RAS Variants of Unknown Significance.

Park S et al.

Cancer Research Communications, 2025

40970755 (PubMed )
Supplement: crc-25-0188_supplementary_table_s4_suppst4.xlsx › Supplementary_Table_S4

An Autopsy Case of Neurofibromatosis Type 1 Mutation Detected in a Duodenal Lesion of Malignant Melanoma: A Case Report.

Seki M et al.

Cureus, 2025

Comprehensive Genomic Profiling of Indian Patients With Lung Cancer.

Sharma S et al.

Jco Global Oncology, 2025

40324118 (PubMed )
Supplement: DS1_GO-24-00587.pdf

Performance Comparison of Droplet Digital PCR and Next-Generation Sequencing for Circulating Tumor DNA Detection in Non-Metastatic Rectal Cancer.

Szeto S et al.

Cancer Medicine, 2025

40346007 (PubMed )
Supplement: CAM4-14-e70943-s001.docx

How to combine multiple tools for the genetic diagnosis work-up of pediatric B-cell acute lymphoblastic leukemia.

Hidalgo-Gómez G et al.

Annals of Hematology, 2025

39843811 (PubMed )
Supplement: 277_2024_6151_MOESM1_ESM.xlsx › S1._Genetics_data

Comparative analysis of RNA expression in a single institution cohort of pediatric cancer patients.

Vasquez YA et al.

Npj Precision Oncology, 2025

40119139 (PubMed )
Supplement: 41698_2025_852_MOESM11_ESM.xlsx › Supplementary_Data_9

Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition.

Zhang T et al.

Biorxiv : the Preprint Server for Biology, 2025

40161734 (PubMed )
Supplement: media-2.xlsx › Supplementary_Table_4

Genomic Landscapes of Early-Onset Versus Average-Onset Colorectal Cancer Populations.

Storandt MH et al.

Cancers, 2025

40075683 (PubMed )
Supplement: cancers-17-00836-s001.zip › cancers-3446894-supplementary.pdf

Recurrent ETV3::NCOA2 fusions and MAPK pathway mutations in indeterminate dendritic cell histiocytosis.

Kemps PG et al.

Blood Advances, 2025

39361730 (PubMed )
Supplement: BLOODA_ADV-2024-013696-mmc1.pdf

Molecular identification of KRAS, BRAF, and PIK3CA mutations in colorectal cancer patients from the Kurdistan region of Iraq.

Hamasharif HG

Molecular Biology Research Communications, 2025

Limited Efficacy of Anti-EGFR Monoclonal Antibodies in Colorectal Cancer Patients with Rare RAS Variants: Analysis of the C-CAT Database.

Suzuki S et al.

Current Issues in Molecular Biology, 2024

Association of SIGLEC9 Expression with Cytokine Expression, Tumor Grading, KRAS, NRAS, BRAF, PIK3CA, AKT Gene Mutations, and MSI Status in Colorectal Cancer.

Ochman B et al.

Current Issues in Molecular Biology, 2024

Indeterminate DC histiocytosis is distinct from LCH and often associated with other hematopoietic neoplasms.

Ozkaya N et al.

Blood Advances, 2024

39361706 (PubMed )
Supplement: BLOODA_ADV-2024-013545-mmc1.xlsx › Sheet1

Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.

Kwon JJ et al.

Biorxiv : the Preprint Server for Biology, 2024

39484452 (PubMed )
Supplement: media-1.pdf

Associations of SEMA7A, SEMA4D, ADAMTS10, and ADAM8 with KRAS, NRAS, BRAF, PIK3CA, and AKT Gene Mutations, Microsatellite Instability Status, and Cytokine Expression in Colorectal Cancer Tissue.

Ochman B et al.

Current Issues in Molecular Biology, 2024

Molecular characterization of Chinese patients with small bowel adenocarcinoma.

Jin B et al.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2024

Exploring the Relationship Between KRAS, NRAS, and BRAF Mutations and Clinical Characteristics in Iranian Colorectal Cancer Patients.

Mosaferi Z et al.

Journal of Gastrointestinal Cancer, 2024

Tumor-derived RHOA mutants interact with effectors in the GDP-bound state.

Lin Y et al.

Nature Communications, 2024

1q jumping translocation as a biomarker in myeloid malignancy: frequently mutated genes associated with bad prognosis and low survival.

Halper-Stromberg E et al.

Experimental Hematology & Oncology, 2024

39090734 (PubMed )
Supplement: 40164_2024_541_MOESM1_ESM.pdf

KRAS Mutation Subtypes and Their Association with Other Driver Mutations in Oncogenic Pathways.

Mondal K et al.

Cells, 2024

Dynamics of RAS Mutations in Liquid Biopsies in Metastatic Colorectal Cancer Patients-Case Series and Literature Review.

Popescu I et al.

Journal of Personalized Medicine, 2024

39064004 (PubMed )
Supplement: jpm-14-00750-s001.zip › jpm-3006960-supplementary.pdf

Clinical features associated with NeoRAS wild-type metastatic colorectal cancer A SCRUM-Japan GOZILA substudy.

Osumi H et al.

Nature Communications, 2024

Clinical Validation of a Targeted Next-Generation Sequencing Panel for Lymphoid Malignancies.

Artymiuk CJ et al.

The Journal of Molecular Diagnostics : Jmd, 2024

Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations.

Huang CY et al.

Cancer Research, 2024

38587551 (PubMed )
Supplement: can-23-2551_supplementary_tables_suppst.xlsx › Table.S11

Somatic mutations associate with clonal expansion of CD8+ T cells.

Lundgren S et al.

Science Advances, 2024

38848368 (PubMed )
Supplement: sciadv.adj0787_tables_s1_to_s11.zip › adj0787_Tables_S1_to_S11.xlsx › S2

Concurrent NRAS-BRAF variants in metastatic colorectal cancer: a Tunisian case report.

Douik H et al.

Anti-cancer Drugs, 2024

Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors.

Jelinek T et al.

Leukemia, 2024

38493239 (PubMed )
Supplement: 41375_2024_2206_MOESM2_ESM.pdf

Temporal dynamics of RAS mutations in circulating tumor DNA in metastatic colorectal cancer: clinical significance of mutation loss during treatment.

Iguchi K et al.

Journal of Cancer Research and Clinical Oncology, 2024

Epidemiological and clinicopathological features of KRAS, NRAS, BRAF mutations and MSI in Chinese patients with stage I-III colorectal cancer.

Wang W et al.

Medicine, 2024

Mechanisms of Resistance to Tyrosine Kinase Inhibitors in ROS1 Fusion-Positive Nonsmall Cell Lung Cancer.

Zhao X et al.

Clinical Chemistry, 2024

Comparison between next-generation sequencing and multiplex polymerase chain reaction assays for nonsmall-cell lung cancer molecular diagnosis.

Murakami S et al.

Cancer Medicine, 2024

38572952 (PubMed )
Supplement: CAM4-13-e7162-s003.xlsx › DNA_mutations

Targeted next-generation sequencing of 491 lung cancers in clinical practice: Implications for future detection strategy and targeted therapy.

Liu XD et al.

Heliyon, 2024

38496837 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Determination of the Prevalence of Microsatellite Instability, BRAF and KRAS/NRAS Mutation Status in Patients with Colorectal Cancer in Slovakia.

Rendek T et al.

Cancers, 2024

38539463 (PubMed )
Supplement: cancers-16-01128-s001.zip › cancers-2866278-supplementary.pdf

Clinical utility of Next Generation Sequencing of plasma cell-free DNA for the molecular profiling of patients with NSCLC at diagnosis and disease progression.

Del Re M et al.

Translational Oncology, 2024

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.

Kubota Y et al.

Nature Communications, 2024

38418452 (PubMed )
Supplement: 41467_2024_46134_MOESM5_ESM.xlsx › Supplementary_Data_2

Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report.

Gramaça J et al.

World Journal of Gastrointestinal Oncology, 2024

Association of KRAS, NRAS, BRAF and PIK3CA gene mutations with clinicopathological features, prognosis and ring finger protein 215 expression in patients with colorectal cancer.

Wu JB et al.

Biomedical Reports, 2023

Characteristic Mutational Damages in Gastric and Colorectal Adenocarcinomas.

Yermekova S et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2023

Liquid biopsy comprehensive genomic profiling of lung cancer in the Italian population: A real-world experience.

Porta C et al.

Lung Cancer (amsterdam, Netherlands), 2023

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."