Associated Papers
Mutations influence the conformational dynamics of the GDP/KRAS complex.
Shen C et al.
Journal of Biomolecular Structure & Dynamics, 2025
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Kwon JJ et al.
Biorxiv : the Preprint Server for Biology, 2024
Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity.
Yang MH et al.
Cancer Research, 2023
Delineating the RAS Conformational Landscape.
Parker MI et al.
Cancer Research, 2022
35536216 (PubMed )
Supplement: can-22-0804_supplementary_datasets_s1-s4_suppsds1-sds4.xlsx › Supplementary_Dataset_S1
KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface.
Yin G et al.
Iscience, 2020
The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2.
Arrington ME et al.
The Journal of Biological Chemistry, 2020
KIAA1109 gene mutation in surviving patients with Alkuraya-Kučinskas syndrome: a review of literature.
Kumar K et al.
Bmc Medical Genetics, 2020
32590954 (PubMed )
Supplement: 12881_2020_1074_MOESM1_ESM.xlsx › Sheet1
Biology, pathology, and therapeutic targeting of RAS.
Rhett JM et al.
Advances in Cancer Research, 2020
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.
Cai W et al.
Nature Communications, 2019
31863007 (PubMed )
Supplement: 41467_2019_13608_MOESM2_ESM.pdf
K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function.
Cao S et al.
The Journal of Biological Chemistry, 2019
A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation.
Yin G et al.
The Journal of Biological Chemistry, 2017
Insights into K-Ras 4B regulation by post-translational lysine acetylation.
Knyphausen P et al.
Biological Chemistry, 2016
HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS.
Yang MH et al.
Molecular Cancer Research : Mcr, 2013
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