Associated Papers
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Kwon JJ et al.
Biorxiv : the Preprint Server for Biology, 2024
39484452 (PubMed )
Supplement: media-2.zip › Extended_Data_Tables › Extended_Data_Table_3.xlsx › KRAS_G12D_LOF_DMS_Screens
Cell phenotypes can be predicted from propensities of protein conformations.
Nussinov R et al.
Current Opinion in Structural Biology, 2023
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera JA et al.
Brain : a Journal of Neurology, 2023
Analysis of the clinical characteristics and prognosis of adult de novo acute myeloid leukemia (none APL) with PTPN11 mutations.
Sheng L et al.
Open Medicine (warsaw, Poland), 2023
Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.
Chevrier S et al.
International Journal of Molecular Medicine, 2022
35244186 (PubMed )
Supplement: Supplementary_Data2.xlsx › Feuil1
Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2.
Solman M et al.
Frontiers in Cell and Developmental Biology, 2022
The modular network structure of the mutational landscape of Acute Myeloid Leukemia.
Ibáñez M et al.
Plos One, 2018
30303964 (PubMed )
Supplement: pone.0202926.s006.pdf
Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.
Ding LW et al.
Cancer Research, 2017
Structural and mechanistic insights into LEOPARD syndrome-associated SHP2 mutations.
Yu ZH et al.
The Journal of Biological Chemistry, 2013
An unexpected new role of mutant Ras: perturbation of human embryonic development.
Kratz CP et al.
Journal of Molecular Medicine (berlin, Germany), 2007
Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction.
Gelb BD et al.
Human Molecular Genetics, 2006
Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders.
Kratz CP et al.
Cell Cycle (georgetown, Tex.), 2006
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease.
Kratz CP et al.
Blood, 2005
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
Tartaglia M et al.
Nature Genetics, 2003
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