Associated Papers
Functional Analysis of Rare RAS Variants of Unknown Significance.
Park S et al.
Cancer Research Communications, 2025
Structural basis for LZTR1 recognition of RAS GTPases for degradation.
Dharmaiah S et al.
Science (new York, N.y.), 2025
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Kwon JJ et al.
Biorxiv : the Preprint Server for Biology, 2024
Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.
Ratnasinghe BD et al.
Biorxiv : the Preprint Server for Biology, 2023
Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape.
Ratnasinghe BD et al.
Computational and Structural Biotechnology Journal, 2023
Understanding the influence of AMG 510 on the structure of KRASG12C empowered by molecular dynamics simulation.
Li Y et al.
Computational and Structural Biotechnology Journal, 2022
Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutations.
Tripathi S et al.
Bioinformatics (oxford, England), 2021
Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery.
Pálfy G et al.
Cancer Metastasis Reviews, 2020
NMR in integrated biophysical drug discovery for RAS: past, present, and future.
Marshall CB et al.
Journal of Biomolecular Nmr, 2020
Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma.
Maron SB et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2019
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.
Kovalski JR et al.
Molecular Cell, 2019
K-Ras Populates Conformational States Differently from Its Isoform H-Ras and Oncogenic Mutant K-RasG12D.
Parker JA et al.
Structure (london, England : 1993), 2018
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.
Westcott PM et al.
Nature, 2015
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Sasaki AT et al.
Science Signaling, 2011