Associated Papers
Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol.
Spiekman IAC et al.
International Journal of Cancer, 2026
KRAS-G12C: The neglected biomarker to detect patients with MUTYH-associated polyposis.
Medeiros ABD et al.
International Journal of Cancer, 2026
Diagnostic accuracy of next-generation sequencing (NGS) for identifying actionable mutations in advanced non-small cell lung cancer: Systematic Review and Meta-Analysis.
Téllez Castillo N et al.
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026
Quantum mechanics as a tool to decipher the mutational landscape of human disease.
Zavitsanou EI et al.
Progress in Biophysics and Molecular Biology, 2026
Deciphering gain-of-function from loss-of-function variants with AlphaMissense: A case study with the mechanosensitive PIEZO1 ion channel protein.
Pillai J et al.
Biochemistry and Biophysics Reports, 2026
Clinical and molecular characteristics of Class II and III BRAF mutations in colorectal cancer.
Sahin IH et al.
Npj Precision Oncology, 2026
IsoPS-DIA: Dual Functionality of Absolute Targeted Quantification and Global Proteome Profiling.
Chan HJ et al.
Analytical Chemistry, 2026
Impact of KRAS-G12 Mutations on the KRAS-GTP Bound Conformational Dynamics: Structure, Free Energy Barriers and Drugging Pockets.
Hu Z et al.
Jacs Au, 2026
Database of recurrent mutations, an unbiased web resource to browse recurrent mutations in cancers.
Chakroborty D et al.
Iscience, 2026
Transcriptomic and multi-layer variant analysis identifies STAT3 and HIF1A as central regulators of regulated cell death pathways in lung squamous cell carcinoma.
Li X et al.
Naunyn-schmiedeberg's Archives of Pharmacology, 2026
Evolving roles of liquid biopsy in precision medicine for colorectal cancer: from single-gene analysis to broad genomic profiling.
Martini G et al.
Nature Reviews. Clinical Oncology, 2026
A multiplex, prime editing framework for identifying drug resistance variants at scale.
Abadie FMC et al.
Cell Genomics, 2026
Daraxonrasib (RMC-6236) is an effective targeted therapy for RAS -mutant neuroblastoma.
Hill RD et al.
Biorxiv : the Preprint Server for Biology, 2026
Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS.
van Tienen LM et al.
Cell Chemical Biology, 2026
Advances in immunotherapy for colorectal cancer: overcoming resistance in mismatch repair-proficient tumors.
Keivany MR et al.
Cancer Cell International, 2026
Sub-stoichiometric Degradation is Dispensable for Potent PROTACs: A Case Study for Irreversible Covalent BTK Degraders.
Cheng R et al.
Biorxiv : the Preprint Server for Biology, 2026
Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition.
Solomon H et al.
Biorxiv : the Preprint Server for Biology, 2026
Ras-Related Mutants Identified in Young-Onset Colorectal Cancer Display Divergent Phenotypes and Retain Their Pro-Angiogenic Effects.
David APL et al.
Cells, 2026
Targeting SHOC2: a treatable therapeutic site in RAS(Q61) mutant cancers.
Tang J et al.
Science China. Life Sciences, 2026
Structure-Guided Development of NRAS G12D Inhibitors Based on a 5‑Azaindole Core.
Cox JB et al.
Acs Medicinal Chemistry Letters, 2026
Genomic alterations and their correlation with metabolic-related genes in lung cancer.
Gaur G et al.
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026
Somatic copy number variation as a prognostic marker for recurrence in never-smokers with early-stage lung adenocarcinoma.
Vanstraelen S et al.
International Journal of Cancer, 2026
Clinico-genomic characterization of RAS-mutant acute myeloid leukemia.
Yuan R et al.
Annals of Hematology, 2026
Metabolic permissiveness: how tissue context shapes cancer.
Moschandrea C et al.
Genes & Development, 2026
Genomic Profile of Non-Small Cell Lung Cancer in a Spanish Cohort: A 2-Year Descriptive Study Using Next-Generation Sequencing.
Carnero-Gregorio M et al.
Genes, 2026
Rare, Yet Targetable: New Perspectives on Ampullary Carcinomas.
Gutmans J et al.
International Journal of Molecular Sciences, 2026
Braf-mutant metastatic non-small-cell lung cancer: Real world data from the Italian biomarker atlas database.
Sini C et al.
European Journal of Cancer (oxford, England : 1990), 2026
The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.
Michail C et al.
The Journal of Biological Chemistry, 2026
Deconvolving mutation effects on protein stability and function with disentangled protein language models.
Ding K et al.
Biorxiv : the Preprint Server for Biology, 2026
Precision oncology in Bulgaria: a prospective study of metastatic colorectal cancer patients.
Dimitrov G et al.
Cancer Treatment and Research Communications, 2026
PIK3CA Alterations in NSCLC: Clinical Characteristics of a "Neglected" Population of Oncogene-Addicted Patients.
Rossi S et al.
Biomedicines, 2026
Transcriptomic landscape of transposable elements reveals LTR7-PLAAT4 as a potential oncogene and therapeutic target in pancreatic adenocarcinoma.
Shi M et al.
Genome Research, 2026
AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRASG12C mutation colorectal cancer liver metastasis.
Li W et al.
Journal of Experimental & Clinical Cancer Research : Cr, 2026
Structural and Dynamic Insights into Podocalyxin-Ezrin Interaction as a Target in Cancer Progression.
Milutinovic M et al.
Journal of Xenobiotics, 2026
Histomorphological and Molecular Features of Colonic Large-Cell Neuroendocrine Carcinoma in a Patient With Familial Adenomatous Polyposis: A Case Report and Review of Literature.
Moustafa M et al.
International Journal of Surgical Pathology, 2026
Multiplexed assays of variant effect for clinical variant interpretation.
McEwen AE et al.
Nature Reviews. Genetics, 2026
Genetic landscape of cancer: mechanisms, key genes, and therapeutic implications.
Karnwal A et al.
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026
Genomic insights on lung cancer risk: identifying new variants in Amazonian indigenous populations.
Fernandes BM et al.
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026
Application of Targeted RNA-Sequencing in High-Risk B-Cell Acute Lymphoblastic Leukemia (B-ALL): Identifying Fusions, IKZF1 Deletions, and CRLF2 Expression in an Indian Cohort.
Gupta SK et al.
International Journal of Laboratory Hematology, 2026
Using the Reactome Graph Database to generate pathway fingerprints for cancer-related genes, and using the fingerprints to gain insights into cancer, comorbidity, and cancer gene networks.
Iengar P et al.
Computational Biology and Chemistry, 2026
Histopathological associations, molecular findings and clinical outcomes of patients with non-small cell lung carcinoma with MET alterations: a 3-year retrospective Australian case series.
Li JJ et al.
Pathology, 2026
BRAF p.V600E Mutation in Mixed Odontogenic Tumors and Its Clinical Correlation: A Systematic Review and Meta-Analysis.
Chantarangsu S et al.
International Dental Journal, 2026
Real-world clinical utility of comprehensive genomic profiling in advanced solid tumors.
Saito Y et al.
Nature Medicine, 2026
Identifying and capitalizing on unique molecular alterations of mucinous ovarian carcinoma for the development of novel therapeutic strategies.
Jang M et al.
Gynecologic Oncology Reports, 2026
Insights into RAS-driven melanoma and its therapeutic implications.
Chatziioannou E et al.
Cancer Treatment Reviews, 2026
Unveiling a BRAF Signature Proficient in Accurately Capturing Oncogenic Activity and Guiding Prognostic Prediction Across Multiple Cancers.
Yang K et al.
Medcomm, 2026
Tutorial for variant interrogation in tumor samples.
Arseneau RJ et al.
Plos Computational Biology, 2026