Associated Papers
A novel LACC1 variant c.658G>A (p. Asp220Asn) in familial juvenile arthritis: identification and functional analysis.
Alblooshi H et al.
Human Genomics, 2025
Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function.
Li Y et al.
Nature Communications, 2025
Recent advances in enzyme-free and enzyme-mediated single-nucleotide variation assay in vitro.
Xiong E et al.
National Science Review, 2024
[Monogenic variants in Laccase domain-containing 1 (LACC1) as the cause of juvenile arthritis].
Knieper AM et al.
Zeitschrift Fur Rheumatologie, 2024
Clinical characteristics and genotype analysis of a Chinese patient with juvenile arthritis due to novel LACC1 frameshift mutation and literature review.
Wu Y et al.
Molecular Genetics & Genomic Medicine, 2023
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.
Liu Z et al.
Nature Genetics, 2023
Identification of shared loci associated with both Crohn's disease and leprosy in East Asians.
Jung S et al.
Human Molecular Genetics, 2022
LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
Wei Z et al.
Nature, 2022
Genome-wide association study of leprosy in Malawi and Mali.
Gilchrist JJ et al.
Plos Pathogens, 2022
Deep resequencing identifies candidate functional genes in leprosy GWAS loci.
Fava VM et al.
Plos Neglected Tropical Diseases, 2021
LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages.
Omarjee O et al.
The Journal of Experimental Medicine, 2021
New or vanishing frontiers: LACC1-associated juvenile arthritis.
Al-Mayouf SM et al.
International Journal of Pediatrics & Adolescent Medicine, 2021
Family-based genome-wide association study of leprosy in Vietnam.
Gzara C et al.
Plos Pathogens, 2020
Pathway paradigms revealed from the genetics of inflammatory bowel disease.
Graham DB et al.
Nature, 2020
FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.
Cader MZ et al.
Cell, 2020
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
Huang C et al.
Cell Reports, 2019
Biallelic loss-of-function LACC1/FAMIN Mutations Presenting as Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis.
Rabionet R et al.
Scientific Reports, 2019
Biochemistry of Autoinflammatory Diseases: Catalyzing Monogenic Disease.
Beck DB et al.
Frontiers in Immunology, 2019
Association of LACC1, CEBPB-PTPN1, RIPK2 and ADO-EGR2 with ocular Behcet's disease in a Chinese Han population.
Wu P et al.
The British Journal of Ophthalmology, 2018
Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese.
Wang D et al.
American Journal of Human Genetics, 2018
LACC1 Gene Defects in Familial Form of Juvenile Arthritis.
Karacan I et al.
The Journal of Rheumatology, 2018
Using genes to triangulate the pathophysiology of granulomatous autoinflammatory disease: NOD2, PLCG2 and LACC1.
Szymanski AM et al.
International Immunology, 2018
Genetic Susceptibility to Leprosy-From Classic Immune-Related Candidate Genes to Hypothesis-Free, Whole Genome Approaches.
Cambri G et al.
Frontiers in Immunology, 2018
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Huang H et al.
Nature, 2017
Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes.
Lahiri A et al.
Nature Communications, 2017
Lessons from characterization and treatment of the autoinflammatory syndromes.
Aksentijevich I et al.
Current Opinion in Rheumatology, 2017
Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility.
Takeuchi M et al.
Nature Genetics, 2017
Juvenile arthritis caused by a novel FAMIN (LACC1) mutation in two children with systemic and extended oligoarticular course.
Kallinich T et al.
Pediatric Rheumatology Online Journal, 2016
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Cader MZ et al.
Nature Immunology, 2016
LACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis.
Assadi G et al.
Genes and Immunity, 2016
The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data.
Tang X et al.
Nucleic Acids Research, 2014