Associated Papers
LAT encodes T cell activation pathway balance.
Rubin AJ et al.
Biorxiv : the Preprint Server for Biology, 2024
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.
Lo WL et al.
Nature Immunology, 2023
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Miyaji M et al.
Proceedings of the National Academy of Sciences of the United States of America, 2009
Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.
Zhu M et al.
Journal of Immunology (baltimore, Md. : 1950), 2003
Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.
Perez-Villar JJ et al.
Biochemistry, 2002
The transmembrane adapter LAT plays a central role in immune receptor signalling.
Wonerow P et al.
Oncogene, 2001
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
Paz PE et al.
The Biochemical Journal, 2001
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
Zhang W et al.
The Journal of Biological Chemistry, 2000
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