Associated Papers
LAT encodes T cell activation pathway balance.
Rubin AJ et al.
Biorxiv : the Preprint Server for Biology, 2024
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.
Lo WL et al.
Nature Immunology, 2023
Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch.
Dine E et al.
Cell Reports, 2021
Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein.
Goda S et al.
Journal of Immunology (baltimore, Md. : 1950), 2004
Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.
Perez-Villar JJ et al.
Biochemistry, 2002
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
Paz PE et al.
The Biochemical Journal, 2001
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
Zhang W et al.
The Journal of Biological Chemistry, 2000
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