Varaico: Literature-Extracted Genetic Variants

Gene:LAT
Variant:p.Y226F
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LAT

NM_001014987.2:p.Y226F

Associated Papers

LAT encodes T cell activation pathway balance.

Rubin AJ et al.

Biorxiv : the Preprint Server for Biology, 2024

39253472 (PubMed )
Supplement: media-5.xlsx › Sheet1

Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch.

Dine E et al.

Cell Reports, 2021

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.

Perez-Villar JJ et al.

Biochemistry, 2002

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.

Paz PE et al.

The Biochemical Journal, 2001

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.

Zhang W et al.

The Journal of Biological Chemistry, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."