Varaico: Literature-Extracted Genetic Variants

Gene:LATS1
Variant:p.D846A
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LATS1

NM_004690.4:p.D846A

Associated Papers

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.

García-Gutiérrez L et al.

Cell Death & Disease, 2022

IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway.

Quinn NP et al.

Cells, 2021

T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.

Zhang Q et al.

Life Sciences, 2021

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

Pefani DE et al.

Nature Cell Biology, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."