Varaico: Literature-Extracted Genetic Variants

Gene:LCK
Variant:p.K273R
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LCK

NM_005356.5:p.K273R

Associated Papers

LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.

Dey G et al.

Journal of Ovarian Research, 2023

Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.

Venkitachalam S et al.

Oncology Reports, 2011

The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity.

Laham LE et al.

Oncogene, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."