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LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer.
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Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses.
Wu J et al.
Nature Cell Biology, 2021
Suppressor of cytokine signaling 1 interacts with oncogenic lymphocyte-specific protein tyrosine kinase.
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The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity.
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Oncogene, 2000
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