Associated Papers
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Signal Transduction and Targeted Therapy, 2025
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Nature Cell Biology, 2021
IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.
Evnouchidou I et al.
Nature Communications, 2020
A simple and efficient workflow for generation of knock-in mutations in Jurkat T cells using CRISPR/Cas9.
Borowicz P et al.
Scandinavian Journal of Immunology, 2020
T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin-NFAT pathway.
Wong WF et al.
European Journal of Immunology, 2014
Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase.
Sibilski C et al.
The Journal of Biological Chemistry, 2013
Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion.
Nakahira K et al.
Plos One, 2013
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
Lu Y et al.
The Journal of Biological Chemistry, 2003
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Koul D et al.
Oncogene, 2002
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
Cuevas BD et al.
The Journal of Biological Chemistry, 2001
Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade.
Bain G et al.
Nature Immunology, 2001
An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.
Majeti R et al.
Cell, 2000
The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity.
Laham LE et al.
Oncogene, 2000
Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.
Visco C et al.
Biochemistry, 2000
Characterization of TCR-induced receptor-proximal signaling events negatively regulated by the protein tyrosine phosphatase PEP.
Gjörloff-Wingren A et al.
European Journal of Immunology, 1999
Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development.
Seavitt JR et al.
Molecular and Cellular Biology, 1999
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