Associated Papers
Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT.
Mammadli M et al.
Iscience, 2021
The Clinical Aspect of Adaptor Molecules in T Cell Signaling: Lessons Learnt From Inborn Errors of Immunity.
Dinur-Schejter Y et al.
Frontiers in Immunology, 2021
Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.
Thaker YR et al.
The Journal of Biological Chemistry, 2017
Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.
Siggs OM et al.
Journal of Immunology (baltimore, Md. : 1950), 2015
The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.
Huang F et al.
Scientific Reports, 2015
Jarid2 is induced by TCR signalling and controls iNKT cell maturation.
Pereira RM et al.
Nature Communications, 2014
Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk.
Prince AL et al.
Journal of Immunology (baltimore, Md. : 1950), 2014
Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.
Prince AL et al.
Journal of Immunology (baltimore, Md. : 1950), 2014
Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation.
Caton AJ et al.
European Journal of Immunology, 2014
Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells.
Gordon SM et al.
Journal of Immunology (baltimore, Md. : 1950), 2011
T-cell signaling regulated by the Tec family kinase, Itk.
Andreotti AH et al.
Cold Spring Harbor Perspectives in Biology, 2010
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.
Alonzo ES et al.
Journal of Immunology (baltimore, Md. : 1950), 2010
Impaired T-cell development in the absence of Vav1 and Itk.
Raberger J et al.
European Journal of Immunology, 2008
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.
Bezman NA et al.
The Journal of Experimental Medicine, 2008
Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76.
Jordan MS et al.
Immunity, 2008
Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.
Fang N et al.
Journal of Immunology (baltimore, Md. : 1950), 1996