Varaico: Literature-Extracted Genetic Variants

Gene:LCP2
Variant:p.Y128F
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LCP2

NM_005565.5:p.Y128F

Associated Papers

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines.

Thaker YR et al.

The Journal of Biological Chemistry, 2017

Mechanism and function of Vav1 localisation in TCR signalling.

Ksionda O et al.

Journal of Cell Science, 2012

Lymphocyte signaling: beyond knockouts.

Saveliev A et al.

Nature Immunology, 2009

Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.

Bezman NA et al.

The Journal of Experimental Medicine, 2008

Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

Fang N et al.

Journal of Immunology (baltimore, Md. : 1950), 1996

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."