Associated Papers
IMPROVE 2023: The 2nd International Meeting on Pathway-Related Obesity: Vision & Evidence.
Clément K et al.
Clinical Obesity, 2025
Medical semiology of patients with monogenic obesity: A systematic review.
Renard E et al.
Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 2024
Classification of Congenital Leptin Deficiency.
von Schnurbein J et al.
The Journal of Clinical Endocrinology and Metabolism, 2024
Novel compound heterozygous mutations in LEP responsible for obesity in a Chinese family.
Li H et al.
Molecular Genetics and Metabolism Reports, 2024
A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficiencies.
Baird HJM et al.
The Journal of Biological Chemistry, 2024
A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.
Besci Ö et al.
The Journal of Clinical Endocrinology and Metabolism, 2023
Congenital leptin and leptin receptor deficiencies in nine new families: identification of six novel variants and review of literature.
Mazen IH et al.
Molecular Genetics and Genomics : Mgg, 2023
Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity.
Funcke JB et al.
The New England Journal of Medicine, 2023
The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits.
Hinney A et al.
Nature Reviews. Endocrinology, 2022
Leptin Signaling in Obesity and Colorectal Cancer.
Socol CT et al.
International Journal of Molecular Sciences, 2022
Prevalence estimates of putatively pathogenic leptin variants in the gnomAD database.
Rajcsanyi LS et al.
Plos One, 2022
A fresh look to the phenotype in mono-allelic likely pathogenic variants of the leptin and the leptin receptor gene.
Koerber-Rosso I et al.
Molecular and Cellular Pediatrics, 2021
Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution.
Beghini M et al.
International Journal of Obesity (2005), 2021
When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin.
Salum KCR et al.
Frontiers in Endocrinology, 2021
Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency.
Kohlsdorf K et al.
International Journal of Obesity (2005), 2018
Severe Early Onset Obesity due to a Novel Missense Mutation in Exon 3 of the Leptin Gene in an Infant from Northwest India
Dayal D et al.
Journal of Clinical Research in Pediatric Endocrinology, 2018
Estimated prevalence of potentially damaging variants in the leptin gene.
Nunziata A et al.
Molecular and Cellular Pediatrics, 2017
Measurement of immunofunctional leptin to detect and monitor patients with functional leptin deficiency.
Wabitsch M et al.
European Journal of Endocrinology, 2017
The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat.
Xu S et al.
Scientific Reports, 2016
Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene.
Wabitsch M et al.
The Journal of Clinical Endocrinology and Metabolism, 2015
Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population.
Saeed S et al.
Obesity (silver Spring, Md.), 2015
Biologically inactive leptin and early-onset extreme obesity.
Wabitsch M et al.
The New England Journal of Medicine, 2015