Varaico: Literature-Extracted Genetic Variants

Gene:LEP
Variant:p.S114A
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LEP

NM_000230.3:p.S114A

Associated Papers

MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.

Jamaluddin A et al.

Cell Reports, 2026

Association of Mutations in the Melanocortin-2 Receptor Accessory Protein 2 Gene (MRAP2) and Obesity: A Systematic Review and Meta-Analysis.

Ji RL et al.

International Journal of Molecular Sciences, 2026

Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways.

Wyatt RA et al.

Human Molecular Genetics, 2025

Obesity associated with a mutation in a genetic regulator of adipocyte differentiation.

Ristow M et al.

The New England Journal of Medicine, 1998

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."